Dive Brief: AstraZeneca will pay privately held Accent Therapeutics $55 million in a deal to develop cancer drugs that target enzymes which can modify RNA molecules. Disclosure: Disclosure information not submitted. Sickmier, S.M. Case, S. Ribich, R.A. Copeland Accent™ Therapeutics, Lexington, MA METTL3/14: A Type I RNA Methyltransferase • Two distinct biochemical assays utilizing an 11-mer A variety of covalent modifications of RNA have been identified and demonstrated to affect RNA processing, stability, and translation. Accent Therapeutics and AstraZeneca forged a collaboration valued at about $1.1 billion to discover, develop and commercialize transformative therapeutics targeting RNA-modifying proteins (RMPs) for the treatment of cancer. Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. METTL3 is an RNA methyltransferase implicated in AML, specific solid tumors and immuno-oncology. The two will combine their expertise in the field of cancer biology and small … “I like the term RNA epigenetics,” she says. Head of Lead Discovery Accent Therapeutics. Room/Location: 6C. Accent Therapeutics, Lexington, MA, USA See all articles by this author. Accent Therapeutics worked two important pieces into its deal with … The parallels between the well-studied marks on DNA and histones and those on RNA provide a framework for understanding and explaining the biology of RNA modifications, she adds. Storm Therapeutics Ltd. is the first company to come out of the budding field of RNA epigenetics, and is targeting RNA-modifying enzymes for cancer. As well as Accent, Mr Blundy names two other groups that have a similar strategy to Storm in targeting RNA-modifying enzymes: Gotham Therapeutics and 278. METTL3 is an RNA methyltransferase implicated in AML, specific solid tumors and immuno-oncology. CEO Keith Blundy told BioCentury RNA-modifying enzymes fit into the landscape of epigenetic targets because, like DNA-modifying enzymes, they alter gene expression without changing the genetic code. In fact, scientists have found elevated levels of METTL3 in leukemia cells. METTL3, responsible for the most prevalent and best studies of RNA modification, m6A. For Accent, the collaboration with AstraZeneca comes a little more than a month after the company secured $63 million in a Series B funding round to support the development of its own RMP-inhibitors, including its lead programs METTL3 and ADAR1. Since launching in 2018, Accent has advanced a broad pipeline of programs, including its two lead programs – METTL3 and ADAR1. METTL3/14 is a Validated, Druggable Therapeutic Target for AML P.A. Accent Therapeutics has also identified METTL3 inhibitors using a structure-guided approach, and it hopes to have a compound ready for phase I trials for … (Pixabay) Two years ago, Accent Therapeutics got off a $40 million series A to target RNA-modifying proteins … Gotham Therapeutics appears to have a strong focus on Accent Therapeutics 8.00 Opening Keynote Address: Chromatin-modifying and RNA-modifying Enzyme Inhibitors as Precision Cancer Therapeutics ... methyltransferase METTL3 - Introduction to R Introduction to RNA modi cations, the role of METTL3 and the m6A modi cation on October 27, 2019 Accent Presents "METTL3/14 is a Validated, Druggable Therapeutic Target for AML" (AACR-NCI-EORTC 2019) September 3, 2019 Accent Therapeutics Appoints Shakti Narayan as Chief Executive Officer Mass Spectrometric Assay of METTL3/METTL14 Methyltransferase Activity. 今日，Accent Therapeutics公司宣布完成6300万美元B轮融资，以推进其靶向RNA修饰蛋白（RMPs）METTL3和ADAR1的研发项目，并继续扩大其研发管线。 本轮融资由艾伯维风险投资（AbbVie Ventures）和Atlas Venture等投资机构参与。 Sponsored By: Speaker - Not Funded(s) SB. Our mission is to translate extraordinary science to life-changing therapies for patients in need. A series of events beginning in 2008 laid the foundation for epitranscriptomics. Since launching in 2018, Accent has advanced a broad pipeline of programs, including its two lead programs – METTL3 and ADAR1. Accent Therapeutics nabs $63M for RNA cancer push. “The idea of METTL3 in [RNA] circularization is intriguing,” says Robert Copeland, founder, president and CSO of Accent Therapeutics, based in … At least one other company appears to be chasing METTL3: Accent Therapeutics, which last year raised a $63 million B round and announced a co-development deal with AstraZeneca utilizing its RNA-modifying protein platform, has presented in vitro data in AML for its inhibitors of METTL3 and METTL14, another m6A writer. Accent, AstraZeneca take aim at RNA modifiers in $55M cancer pact. Accent Therapeutics and AstraZeneca forged a collaboration valued at about $1.1 billion to discover, develop and commercialize transformative therapeutics targeting RNA-modifying proteins (RMPs) for the treatment of cancer.. Lexington, Mass.-based Accent Therapeutics, which launched in 2018, is focused on epitranscriptomics and the development of novel therapeutics targeting RMPs for cancer. Once generated, m 6 A can modulate mRNA … Hodous, A.W. The Series B was led by EcoR1 Capital with participation by GV, AbbVie Ventures, The Mark Foundation for Cancer Research, NS Investment and Droia Ventures as well as existing investors, Atlas Venture and The Column Group. Methylation of adenosine at the N6 position (m 6 A) in messenger RNA (mRNA) is currently the most well-studied RNA modification and is catalyzed by the RNA methyltransferase complex METTL3/METTL14. Storm Therapeutics is targeting a number of additional undisclosed methyltransferases, whereas Accent Therapeutics has made significant progress in targeting another enzyme, ADAR1, an RNA A-to-I editor. Accent intends to use the proceeds from the financing to advance the development of its novel therapies targeting RNA-modifying proteins (RMPs), including its lead programs ADAR1 and METTL3, and to continue the expansion of its pipeline in the productive target space of RNA modification. METTL3 is an RNA methyltransferase … The Life Sciences team advised Accent Therapeutics on the completion of its $63 million Series B financing. The evidence was particularly shaky for one enzyme, called fat mass and obesity-associated protein, or FTO. J ust weeks after Roche cracked a deal with Vividion therapeutics for leveraging its small molecule discovery (SMD) platform churning E3 ligase inhibitors, AstraZeneca announced that it has made a pact with Accent Therapeutics, an SMD company that develops small molecules targeting RNA modifying proteins (RMP). Storm Therapeutics is targeting a number of additional undisclosed methyltransferases, whereas Accent Therapeutics has made significant progress in targeting another enzyme, ADAR1, an RNA A-to-I editor. METTL3 is an RNA methyltransferase implicated in AML, specific solid tumors, and immuno-oncology. Gotham Therapeutics appears to have a strong focus on ; Lexington, Massachusetts-based Accent will handle the early research and development work under the deal, before handing those responsibilities off to AstraZeneca after Phase 1 testing. Monday, January 27, 2020 3:30 PM – 4:00 PM . This field of biology encompasses post-transcriptional chemical modifications of RNA that provide cells with a unique mechanism for regulating proteins critical for cellular growth and differentiation. Accent Presents “METTL3/14 is a Validated, Druggable Therapeutic Target for AML” (AACR-NCI-EORTC 2019) Careers Our mission is to translate extraordinary science to life-changing therapies … Careers. Proceeds enable advancement of lead program into clinical development and support progression of additional programs. But a studycoming out of the lab of plant biologist Rupert Fray at the University of Nottingham rei… That year, while He was studying epigenetic enzymes that remove methyl modifications from DNA, he and University of Chicago biologist Tao Pan began doubting that all these enzymes were really working on DNA as others assumed. Buker, B.L. It plans to start in AML, but is also eyeing a defined group of solid tumours. Accent Therapeutics is a biopharmaceutical company developing oncology-focused, small molecule therapies in the emerging field of RNA modification. Specific deletion of Mettl3 in Tregs led to loss of Treg suppression function and severe autoimmune diseases. Mr Blundy will not say whether Storm is developing a candidate against METTL3, but agreed that "you might reasonably think we might have an interest in it”. We are looking for driven, creative individuals to accentuate our team: learn more about our values and the benefits of a career at Accent Therapeutics! Ever since Accent launched in 2018, it has advanced a broad pipeline of programs, including its two lead programs – METTL3 and ADAR1. METTL3 is an RNA methyltransferase implicated in AML, specific solid tumors and immuno-oncology. Accent Presents “METTL3/14 is a Validated, Druggable Therapeutic Target for AML” (AACR-NCI-EORTC 2019) Careers Our mission is to translate extraordinary science to … Accent Therapeutics, Gotham Therapeutics and Storm Therapeutics are all targeting proteins involved in RNA methylation to treat cancer and eventually other diseases. (A) 7-week-old Mettl3 f/f; Foxp3Cre … The majority of the m 6 A methylation on mRNA is installed by an enzymatic complex composed of a heterodimer of METTL3 (catalytic core) and METTL14, ... Vitae/Allergan Pharma, Cyteir Therapeutics, C4 Therapeutics, Syros Pharmaceuticals, OxStem Oncology, Accent Therapeutics, and Mana Therapeutics. Accent Therapeutics has prioritized drug discovery efforts on METTL3/METTL14 and potent and selective inhibitors have been identified. Home » Accent Therapeutics presents METTL3 inhibitors. Accent™ Therapeutics, Lexington, MA METTL3/14: A Type I RNA Methyltransferase • Two distinct biochemical assays utilizing an 11-mer RNA substrate containing a central DRACH sequence were developed8 • SPR assays were established for hit validation, characterization of initial hits and lead series Accent Therapeutics has also identified METTL3 inhibitors using a structure- guided approach, and it hopes to have a compound ready for phase I trials for 2021.
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